Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

Although Wnt signaling is considered a key regulatory pathway for bone formation, inactivation of β-catenin in osteoblasts does not affect their activity but rather causes increased osteoclastogenesis due to insufficient production of osteoprotegerin (Opg). By monitoring the expression pattern of all known genes encoding Wnt receptors in mouse tissues and bone cells we identified Frizzled 8 (Fz...

The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy

Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...

PTK7/Otk interacts with Wnts and inhibits canonical Wnt signaling

SEN461 inhibits canonical Wnt signaling and glioblastoma growth

Authors’ Affiliations: Unit of Molecular Oncology, Unit of in vivo Pharmacology, Department of Medicinal Chemistry, Department of Biomolecular Screening, Clinical Development and Department of Pharmacology, Siena Biotech Medicine Research Centre, Siena, Italy. Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. The F. M. Kirby Neurobiolo...

Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling

Many adaptor proteins involved in endocytic cargo transport exhibit additional functions in other cellular processes which may be either related to or independent from their trafficking roles. The endosomal adaptor protein Tollip is an example of such a multitasking regulator, as it participates in trafficking and endosomal sorting of receptors, but also in interleukin/Toll/NF-κB signaling, bac...